Vitamin D by J. Wesley Pike, Francis H. Glorieux, David Feldman – Second Editon
Vitamin D, a new textbook edited by Feldman, Glorieux, and Pike, has enough chicken wire to fence in a farm, but most of it is very interesting. There are about 30 naturally occurring metabolites of vitamin D and more than 800 synthetic analogues designed to treat a variety of diseases, ranging from rickets to cancer.
A slight twist in the molecule, an extra double bond, or an additional carbon atom can change the metabolism, the half-life, the pattern of binding to vitamin D-binding protein, the action of the vitamin D receptor, or perhaps the heterodimer formation and attachment to the vitamin D-response elements on the DNA. These structure-function relations, as well as each step of vitamin D metabolism and action, are clearly detailed in the book.
The chapters are generally well written, beginning with the remarkable history of vitamin D and ending with summaries of preliminary clinical trials of the new vitamin D analogues that have the potential to treat cancer. In between are sections on physiology and clinical disorders related to vitamin D.
Some of the best chapters are those by the editors, including the introduction to the vitamin D receptor by Pike, “Vitamin D Pseudodeficiency” by Glorieux and St.-Arnaud, and “Hereditary 1,25-Dihydroxyvitamin D Resistant Rickets” by Malloy, Pike, and Feldman. Other highlights include the discussion of calcium economy by Heaney, the explanation of dimerization by Freedman and Lemon, the review of vitamin D insufficiency in the elderly by Chapuy and Meunier, the collection of radiographs of patients with rickets by Judith Adams, and the chapter about the role of vitamin D in lymphoproliferative diseases by John Adams.
Publisher: Academic Press; 2 edition (January 6, 2005)
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